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醫(yī)學免費論文:布托啡諾與舒芬太尼聯(lián)合用于食管腫瘤切除術(shù)后患者自控靜脈鎮(zhèn)痛的效果
【摘要】 目的 研究布托啡諾與舒芬太尼聯(lián)合應用于食管腫瘤切除術(shù)后患者自控靜脈鎮(zhèn)痛(patient-controlled intravenous analgesia，PCIA)的臨床效果及其安全性。方法 60例ASAⅠ～Ⅲ級的食管腫瘤患者，隨機均分為3組行PCIA。B組:布托啡諾0.15 mg/kg;S組：舒芬太尼2 μg /kg;BS組(布托啡諾0.075 mg/kg+舒芬太尼1 μg/kg)。監(jiān)測并記錄術(shù)后4、12、24、48 h患者的鎮(zhèn)痛(VAS評分)和鎮(zhèn)靜(Ramsay評分)效果及副作用發(fā)生情況。結(jié)果 3組鎮(zhèn)痛效果均確切可靠。B組VAS評分顯著高于S組和BS組 (P<0.05);S組和BS組之間差異無顯著性(P>0.05)。B組患者Ramsay評分顯著高于S組和BS組(P<0.05);S組和BS 組之間差異無顯著性(P>0.05)。BS組不良反應發(fā)生例數(shù)顯著低于其余兩組(P<0.05)。結(jié)論 布托啡諾與舒芬太尼聯(lián)合應用于食管腫瘤術(shù)后PCIA，鎮(zhèn)痛效果確切可靠而不良反應少，是一種理想的鎮(zhèn)痛方式。
【關(guān)鍵詞】 布托啡諾;舒芬太尼;患者自控靜脈鎮(zhèn)痛
Efficiency of patient-controlled intravenous analgesia with butorphanol and
sufentanil following resection of esophageal carcinoma
JIAO Hao, QI Dunyi, LIU Gongjian
(Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, China)
Abstract: Objective To evaluate the efficacy and safety of butorphanol and sufentanil in patient-controlled intravenous analgesia (PCIA) subsequent to esophageal carcinoma resection. Methods 60 ASA Ⅰ to Ⅲ patients undergoing elective resection for esophageal carcinoma were randomized into 3 groups, who received PCIA with 0.15 mg/kg butorphanol (group B), 2 μg/kg sufentanil (group S) and 0.075 mg/kg butorphanol with 1 μg/kg sufentanil (group BS), respectively. The efficacy and side effects were evaluated by VAS scores and Ramsay scores at 4, 12, 24, 48 hours after operation. Results All the patients showed good relief with PCIA, but VAS scores of group B was significantly higher than those of groups S and BS (P<0.05). There were no significant differences in VAS scores between group S and group BS (P>0.05). The Ramsay scores of group B were significantly higher than those of group S and group BS (P<0.05). There were no significant differences in Ramsay scores between group S and group BS (P>0.05). The prevalence of side effects in group BS was significantly lower than that in other groups. Conclusion Butorphanol combined with sufentanyl in PCIA exhibits good effect of analgesia and minor adverse reactions; which enables a safer and more effective method of analgesia醫(yī).學全.在.線網(wǎng)站52667788.cn.
Key words: butorphanol; sufentanyl; patient-controlled intravenous analgesia
