公開(公告)號 | CN1436234A |
公開(公告)日 | 2003.08.13 |
申請(專利)號 | CN01806526.0 |
申請日期 | 2001.01.16 |
專利名稱 | 用于前列腺癌治療和診斷的組合物及方法 |
主分類號 | C12N15/12 |
分類號 | C12N15/12;C12N15/11;C12N1/21;C12N5/10;C07K14/47;C07K16/18;C07K19/00;A61K38/17;A61K48/00;G01N33/68;C12Q1/68;C12N5/08 |
分案原申請?zhí)? | |
優(yōu)先權 | 2000.1.14 US 09/483,672 |
申請(專利權)人 | 科里克薩有限公司 |
發(fā)明(設計)人 | 徐江春;D·C·迪隆;J·L·密特查姆 |
地址 | 美國華盛頓州 |
頒證日 | |
國際申請 | PCT/US01/01574 2001.1.16 |
進入國家日期 | 2002.09.13 |
專利代理機構 | 中國國際貿(mào)易促進委員會專利商標事務所 |
代理人 | 唐偉杰 |
國省代碼 | 美國;US |
主權項 | 一種分離的多核苷酸,其含有選自下列的序列:(a)SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示的序列;(b)SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列的互補序列;(c)由SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列的至少20個連續(xù)殘基組成的序列;(d)在中度嚴格條件下可與SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列雜交的序列;(e)與SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列有至少75%同一性的序列;(f)與SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列有至少90%同一性的序列;和(g)SEQ ID NO:1-111,115-171,173-175,177,179-305,307-315,326,328,330,332-335,340-375,381,382和384-476,524,526,530,531,533,535,536,552,569-572,587,591,593-606,618-626,630,631,634,636,639-655,674,680,681,711,713,716,720-722,735,737-739,751,753,764,765,773-776和786-788所示序列的簡并變體。 |
摘要 | 公開了用于治療和診斷癌癥(特別是前列腺癌)的組合物和方法。說明性組合物含有一種或多種前列腺特異的多肽、其免疫原部分、編碼這些多肽的多核苷酸、表達這些多肽的抗原遞呈細胞,和對于表達這些多肽的細胞特異的T細胞。例如,公開的這些組合物可用于診斷、預防和/或治療疾病,特別是前列腺癌。 |
國際公布 | WO01/51633 英 2001.7.19 |